Version 5.4
Bos taurus Protein: ISG20L2
Summary
InnateDB Protein IDBP-683004.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISG20L2
Protein Name Interferon-stimulated 20 kDa exonuclease-like 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001989
InnateDB Gene IDBG-631465 (ISG20L2)
Protein Structure
UniProt Annotation
Function 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group. {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0008152 metabolic process
GO:0042254 ribosome biogenesis
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR002562 3\'-5\' exonuclease domain
IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
PFAM PF01612
PF00929
PRINTS
PIRSF
SMART SM00474
SM00479
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2YDK1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515980
UniGene Bt.80589
RefSeq NP_001039682
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110186
GenPept AAI10187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca