InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DNAJC2

Summary

InnateDB Protein

IDBP-683025.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC2

Protein Name

DnaJ homolog subfamily C member 2

Synonyms

ZRF1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004925

InnateDB Gene

IDBG-631482 (DNAJC2)

Protein Structure

UniProt Annotation

Function

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00624}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0042393	histone binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001005 SANT/Myb domain
IPR001623 DnaJ domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain

PFAM

PF00249
PF00226

PRINTS

PR00625

PIRSF

SMART

SM00717
SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1RMH9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

507897

UniGene

Bt.61294

RefSeq

NP_001068805

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114887

GenPept

AAI14888