Version 5.4
Bos taurus Protein: DPT
Summary
InnateDB Protein IDBP-683055.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPT
Protein Name Dermatopontin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028263
InnateDB Gene IDBG-631515 (DPT)
Protein Structure
UniProt Annotation
Function Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. {ECO:0000269PubMed:1939376, ECO:0000269PubMed:9895299}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:1939376}.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, heart, pancreas, skin and cultured fibroblasts. {ECO:0000269PubMed:8907183}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0030199 collagen fibril organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19427
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504963
UniGene Bt.40988
RefSeq NP_001039368
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113221
GenPept AAI13222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca