Version 5.4
| Bos taurus Protein: NFKBIZ | |||||||
|---|---|---|---|---|---|---|---|
| Summary | |||||||
| InnateDB Protein | IDBP-683150.2 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | NFKBIZ | ||||||
| Protein Name | NF-kappa-B inhibitor zeta | ||||||
| Synonyms | MAIL; | ||||||
| Species | Bos taurus | ||||||
| Ensembl Protein | ENSBTAP00000014591 | ||||||
| InnateDB Gene | IDBG-631581 (NFKBIZ) | ||||||
| Protein Structure |
|
||||||
| UniProt Annotation | |||||||
| Function | Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Nucleus {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | |||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
|
||||||
| Gene Ontology | |||||||
Molecular Function |
|
||||||
| Biological Process |
|
||||||
| Cellular Component |
|
||||||
| Protein Structure and Domains | |||||||
| PDB ID | |||||||
| InterPro |
IPR002110
Ankyrin repeat IPR020683 Ankyrin repeat-containing domain |
||||||
| PFAM |
PF00023
PF13606 PF11929 PF12796 |
||||||
| PRINTS |
PR01415
|
||||||
| PIRSF | |||||||
| SMART |
SM00248
|
||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q9BE45 | ||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | M5AKL7 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 282713 | ||||||
| UniGene | Bt.8227 | ||||||
| RefSeq | |||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AB058410 AB438102 BC153257 | ||||||
| GenPept | AAI53258 BAB39767 BAN09040 | ||||||