InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SLC46A1

Summary

InnateDB Protein

IDBP-683195.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC46A1

Protein Name

Proton-coupled folate transporter

Synonyms

TRPE;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035161

InnateDB Gene

IDBG-631639 (SLC46A1)

Protein Structure

UniProt Annotation

Function

Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. {ECO:0000250UniProtKB:Q96NT5, ECO:0000269PubMed:17335806}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:17335806}; Multi-pass membrane protein {ECO:0000269PubMed:17335806}. Cytoplasm {ECO:0000250UniProtKB:Q96NT5}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in internal cellular compartments in iron-replete cells. {ECO:0000250UniProtKB:Q96NT5, ECO:0000269PubMed:17335806}.

Disease Associations

Tissue Specificity

Expressed in retina and retinal pigment epithelium. {ECO:0000269PubMed:17335806}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005542	folic acid binding
GO:0008517	folic acid transporter activity
GO:0015232	heme transporter activity

Biological Process

GO:0006810	transport
GO:0015884	folic acid transport
GO:0015886	heme transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q05B81

PhosphoSite