Bos taurus Protein: NOD2
InnateDB Protein IDBP-683198.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOD2
Protein Name Nucleotide-binding oligomerization domain-containing protein 2
Synonyms CARD15;
Species Bos taurus
Ensembl Protein ENSBTAP00000027887
InnateDB Gene IDBG-631640 (NOD2)
Protein Structure
UniProt Annotation
Function Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0032500 muramyl dipeptide binding
GO:0042834 peptidoglycan binding
GO:0050700 CARD domain binding
Biological Process
GO:0002227 innate immune response in mucosa
GO:0002253 activation of immune response
GO:0002367 cytokine production involved in immune response
GO:0002376 immune system process
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002710 negative regulation of T cell mediated immunity
GO:0002830 positive regulation of type 2 immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006963 positive regulation of antibacterial peptide biosynthetic process
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0016045 detection of bacterium
GO:0030277 maintenance of gastrointestinal epithelium
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0032498 detection of muramyl dipeptide
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032701 negative regulation of interleukin-18 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0035419 activation of MAPK activity involved in innate immune response
GO:0035556 intracellular signal transduction
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046645 positive regulation of gamma-delta T cell activation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0071608 macrophage inflammatory protein-1 alpha production
GO:0090022 regulation of neutrophil chemotaxis
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000363 positive regulation of prostaglandin-E synthase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0008180 COP9 signalosome
GO:0009986 cell surface
GO:0031982 vesicle
GO:0043234 protein complex
Protein Structure and Domains
InterPro IPR001315 CARD domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00619
Post-translational Modifications
SwissProt Q6E804
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 444867
UniGene Bt.30778
RefSeq NP_001002889
EMBL AY518737 AY518739 AY518740 AY518741 AY518742 AY518743 AY518744 AY518745 AY518746 AY518747 AY518748
GenPept AAS09824 AAS09826