InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NOD2

Summary

InnateDB Protein

IDBP-683198.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOD2

Protein Name

Nucleotide-binding oligomerization domain-containing protein 2

Synonyms

CARD15;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027887

InnateDB Gene

IDBG-631640 (NOD2)

Protein Structure

UniProt Annotation

Function

Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0032500	muramyl dipeptide binding
GO:0042834	peptidoglycan binding
GO:0050700	CARD domain binding

Biological Process

GO:0002227	innate immune response in mucosa
GO:0002253	activation of immune response
GO:0002367	cytokine production involved in immune response
GO:0002376	immune system process
GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002710	negative regulation of T cell mediated immunity
GO:0002830	positive regulation of type 2 immune response
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006963	positive regulation of antibacterial peptide biosynthetic process
GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0016045	detection of bacterium
GO:0030277	maintenance of gastrointestinal epithelium
GO:0031398	positive regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032494	response to peptidoglycan
GO:0032495	response to muramyl dipeptide
GO:0032496	response to lipopolysaccharide
GO:0032498	detection of muramyl dipeptide
GO:0032689	negative regulation of interferon-gamma production
GO:0032695	negative regulation of interleukin-12 production
GO:0032701	negative regulation of interleukin-18 production
GO:0032703	negative regulation of interleukin-2 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032731	positive regulation of interleukin-1 beta production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
GO:0035419	activation of MAPK activity involved in innate immune response
GO:0035556	intracellular signal transduction
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0043410	positive regulation of MAPK cascade
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0046645	positive regulation of gamma-delta T cell activation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766	positive regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium
GO:0050871	positive regulation of B cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224	cellular response to peptidoglycan
GO:0071225	cellular response to muramyl dipeptide
GO:0071608	macrophage inflammatory protein-1 alpha production
GO:0090022	regulation of neutrophil chemotaxis
GO:2000110	negative regulation of macrophage apoptotic process
GO:2000363	positive regulation of prostaglandin-E synthase activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0009986	cell surface
GO:0031982	vesicle
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619

PRINTS

PIRSF

SMART

SM00114
SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6E804