InnateDB Protein
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IDBP-683265.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IFT57
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Protein Name
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Intraflagellar transport protein 57 homolog
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Synonyms
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ESRRBL1;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000007606
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InnateDB Gene
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IDBG-631710 (IFT57)
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Protein Structure
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Function |
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:11916979}. Note=Concentrates within the inner segment of cilia.
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Disease Associations |
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Tissue Specificity |
In retina, detected in the photoreceptor basal body and connecting cilium. Most abundant in the inner segment of photoreceptors (at protein level). {ECO:0000269PubMed:11916979}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010989
t-SNARE
IPR019530
Intra-flagellar transport protein 57
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PFAM |
PF10498
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5EA95
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
531436
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UniGene |
Bt.52335
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RefSeq |
NP_001098873
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC151565
BT020674
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GenPept |
AAI51566
AAX08691
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