InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CSK

Summary

InnateDB Protein

IDBP-683284.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSK

Protein Name

Tyrosine-protein kinase CSK

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028559

InnateDB Gene

IDBG-631733 (CSK)

Protein Structure

UniProt Annotation

Function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0002376	immune system process
GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0042997	negative regulation of Golgi to plasma membrane protein transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00401
PR00109
PR00452

PIRSF

SMART

SM00252
SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VBZ0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509246

UniGene

Bt.20371

RefSeq

NP_001068865

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120437

GenPept

AAI20438