Version 5.4
Bos taurus Protein: DOCK8
Summary
InnateDB Protein IDBP-683301.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK8
Protein Name dedicator of cytokinesis 8
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002840
InnateDB Gene IDBG-631748 (DOCK8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001771 immunological synapse formation
GO:0007264 small GTPase mediated signal transduction
GO:0036336 dendritic cell migration
GO:0043547 positive regulation of GTPase activity
GO:0061485 memory T cell proliferation
GO:0070233 negative regulation of T cell apoptotic process
Cellular Component
GO:0016020 membrane
GO:0031252 cell leading edge
Protein Structure and Domains
PDB ID
InterPro IPR010703 Dedicator of cytokinesis C-terminal
IPR016024 Armadillo-type fold
IPR021816 Dedicator of cytokinesis C/D, N-terminal
PFAM PF06920
PF11878
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BNA6
UniProt Splice Variant
Entrez Gene 100295817
UniGene Bt.9456
RefSeq NP_001178461
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02022784 DAAA02022785 DAAA02022786
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca