Version 5.4
Bos taurus Protein: FXN
Summary
InnateDB Protein IDBP-683414.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXN
Protein Name Frataxin, mitochondrialFrataxin intermediate formFrataxin mature form
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001725
InnateDB Gene IDBG-631850 (FXN)
Protein Structure
UniProt Annotation
Function Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004322 ferroxidase activity
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0034986 iron chaperone activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006119 oxidative phosphorylation
GO:0006783 heme biosynthetic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006879 cellular iron ion homeostasis
GO:0007005 mitochondrion organization
GO:0007628 adult walking behavior
GO:0008284 positive regulation of cell proliferation
GO:0009060 aerobic respiration
GO:0009792 embryo development ending in birth or egg hatching
GO:0010039 response to iron ion
GO:0010722 regulation of ferrochelatase activity
GO:0016226 iron-sulfur cluster assembly
GO:0016540 protein autoprocessing
GO:0018283 iron incorporation into metallo-sulfur cluster
GO:0019230 proprioception
GO:0030307 positive regulation of cell growth
GO:0040015 negative regulation of multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0046621 negative regulation of organ growth
GO:0048554 positive regulation of metalloenzyme activity
GO:0051347 positive regulation of transferase activity
GO:0051349 positive regulation of lyase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0055072 iron ion homeostasis
GO:0055114 oxidation-reduction process
GO:0070301 cellular response to hydrogen peroxide
GO:0090201 negative regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR002908 Frataxin/CyaY
IPR017789 Frataxin
PFAM PF01491
PRINTS PR00904
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05B87
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505694
UniGene Bt.17029
RefSeq NP_001074196
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122620
GenPept AAI22621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca