InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SRD5A1

Summary

InnateDB Protein

IDBP-683490.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRD5A1

Protein Name

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Synonyms

S5AR 1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020570

InnateDB Gene

IDBG-631916 (SRD5A1)

Protein Structure

UniProt Annotation

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). {ECO:0000250}.

Subcellular Localization

Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0047751	cholestenone 5-alpha-reductase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006702	androgen biosynthetic process
GO:0007548	sex differentiation
GO:0008202	steroid metabolic process
GO:0030154	cell differentiation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
IPR010721 Protein of unknown function DUF1295
IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase

PFAM

PF02544
PF06966

PRINTS

PIRSF

PIRSF015596

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PJS2