Version 5.4
Bos taurus Protein: IRG1
Summary
InnateDB Protein IDBP-683505.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRG1
Protein Name immunoresponsive 1 homolog (mouse)
Synonyms IRG1;
Species Bos taurus
Ensembl Protein ENSBTAP00000010869
InnateDB Gene IDBG-631926 (IRG1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0047547 2-methylcitrate dehydratase activity
GO:0047613 aconitate decarboxylase activity
Biological Process
GO:0002760 positive regulation of antimicrobial humoral response
GO:0006952 defense response
GO:0007566 embryo implantation
GO:0008152 metabolic process
GO:0019543 propionate catabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0045824 negative regulation of innate immune response
GO:0050728 negative regulation of inflammatory response
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071393 cellular response to progesterone stimulus
GO:0072573 tolerance induction to lipopolysaccharide
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR005656 MmgE/PrpD
PFAM PF03972
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MGW6
UniProt Splice Variant
Entrez Gene 504806
UniGene
RefSeq XP_002691944
HUGO HGNC:33904
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02033604 DAAA02033605 DAAA02033606
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca