InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NSDHL

Summary

InnateDB Protein

IDBP-683539.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSDHL

Protein Name

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012167

InnateDB Gene

IDBG-631956 (NSDHL)

Protein Structure

UniProt Annotation

Function

Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Note=Trafficking through the Golgi is necessary for ER membrane localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047012	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0050662	coenzyme binding

Biological Process

GO:0001942	hair follicle development
GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0007224	smoothened signaling pathway
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0009058	biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR008030 NmrA-like domain
IPR013120 Male sterility, NAD-binding

PFAM

PF01370
PF01073
PF02719
PF04321
PF05368
PF07993

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBE9

PhosphoSite