Version 5.4
Bos taurus Protein: CCNC
Summary
InnateDB Protein IDBP-683695.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNC
Protein Name Cyclin-C
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000037680
InnateDB Gene IDBG-632100 (CCNC)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
IPR023598 Cyclin C
PFAM PF00134
PRINTS
PIRSF PIRSF028758
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZCK5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509717
UniGene Bt.16282
RefSeq NP_001029530
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102107
GenPept AAI02108

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca