InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.60929

Summary

InnateDB Protein

IDBP-683784.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.60929

Protein Name

telomerase reverse transcriptase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016685

InnateDB Gene

IDBG-632169 (BT.60929)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003720	telomerase activity
GO:0003721	telomeric template RNA reverse transcriptase activity
GO:0003723	RNA binding
GO:0003964	RNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0070034	telomeric RNA binding

Biological Process

GO:0006278	RNA-dependent DNA replication
GO:0007004	telomere maintenance via telomerase
GO:0022616	DNA strand elongation
GO:0032203	telomere formation via telomerase
GO:0090399	replicative senescence
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005697	telomerase holoenzyme complex
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR000477 Reverse transcriptase domain
IPR003545 Telomerase reverse transcriptase
IPR016187 C-type lectin fold
IPR021891 Telomerase ribonucleoprotein complex - RNA-binding domain

PFAM

PF00078
PF12009

PRINTS

PR01365

PIRSF

SMART

SM00975

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt