InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GBA

Summary

InnateDB Protein

IDBP-683792.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GBA

Protein Name

glucosylceramidase precursor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019765

InnateDB Gene

IDBG-632188 (GBA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004348	glucosylceramidase activity
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006665	sphingolipid metabolic process
GO:0006680	glucosylceramide catabolic process
GO:0023021	termination of signal transduction
GO:0032715	negative regulation of interleukin-6 production
GO:0035307	positive regulation of protein dephosphorylation
GO:0043407	negative regulation of MAP kinase activity
GO:0046512	sphingosine biosynthetic process
GO:0046513	ceramide biosynthetic process
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005765	lysosomal membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001139 Glycoside hydrolase, family 30
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF02055

PRINTS

PR00843

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G9BHQ1

UniProt Splice Variant

Entrez Gene

537087

UniGene

Bt.5413

RefSeq

NP_001039886

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02007156 HQ585472

GenPept

AEA11410