InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MUC1

Summary

InnateDB Protein

IDBP-683803.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MUC1

Protein Name

Mucin-1Mucin-1 subunit alphaMucin-1 subunit beta

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014051

InnateDB Gene

IDBG-632205 (MUC1)

Protein Structure

UniProt Annotation

Function

The alpha subunit has cell adhesive properties. May provide a protective layer on epithelial cells against bacterial and enzyme attack (By similarity). {ECO:0000250}.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, Src and NF- kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane (By similarity). {ECO:0000250}.Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed on the apical surface of epithelia cells, and on the milk fat globule membrane (MGGM).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane