Version 5.4
Bos taurus Protein: VAMP4
Summary
InnateDB Protein IDBP-683822.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAMP4
Protein Name Vesicle-associated membrane protein 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027435
InnateDB Gene IDBG-632221 (VAMP4)
Protein Structure
UniProt Annotation
Function Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016192 vesicle-mediated transport
GO:0035493 SNARE complex assembly
GO:0042996 regulation of Golgi to plasma membrane protein transport
GO:0043001 Golgi to plasma membrane protein transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031201 SNARE complex
Protein Structure and Domains
PDB ID
InterPro IPR001388 Synaptobrevin
PFAM PF00957
PRINTS PR00219
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32L97
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 616923
UniGene
RefSeq NP_001069906
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109690 BC142401
GenPept AAI09691 AAI42402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca