InnateDB Protein
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IDBP-683835.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EFNA1
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Protein Name
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Ephrin-A1Ephrin-A1, secreted form
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000004007
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InnateDB Gene
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IDBG-632234 (EFNA1)
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Protein Structure
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Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.Ephrin-A1, secreted form: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001799
Ephrin
IPR008972
Cupredoxin
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PFAM |
PF00812
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PRINTS |
PR01347
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3ZC64
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
507319
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UniGene |
Bt.91163
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RefSeq |
NP_001029464
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102889
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GenPept |
AAI02890
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