Version 5.4
Bos taurus Protein: MMS22L
Summary
InnateDB Protein IDBP-683864.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMS22L
Protein Name Protein MMS22-like
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000830
InnateDB Gene IDBG-632227 (MMS22L)
Protein Structure
UniProt Annotation
Function Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0031297 replication fork processing
Cellular Component
GO:0005634 nucleus
GO:0035101 FACT complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BGH8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 532916
UniGene Bt.40018
RefSeq NP_001192941
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03054673 AAFC03056615
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca