Version 5.4
Bos taurus Protein: UFL1
Summary
InnateDB Protein IDBP-683896.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UFL1
Protein Name E3 UFM1-protein ligase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027202
InnateDB Gene IDBG-632284 (UFL1)
Protein Structure
UniProt Annotation
Function E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1. The function of ufmylation is unknown (By similarity). May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cytoplasm colocalizes with CDK5RAP3. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0071568 UFM1 conjugating enzyme activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0031397 negative regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0071569 protein ufmylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR018611 E3 UFM1-protein ligase 1
PFAM PF09743
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1A4I9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515894
UniGene Bt.24053
RefSeq NP_001073745
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126563
GenPept AAI26564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca