Version 5.4
Bos taurus Protein: CELA1
Summary
InnateDB Protein IDBP-683898.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CELA1
Protein Name Chymotrypsin-like elastase family member 1
Synonyms ELA1;
Species Bos taurus
Ensembl Protein ENSBTAP00000011718
InnateDB Gene IDBG-632294 (CELA1)
Protein Structure
UniProt Annotation
Function Acts upon elastin.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0009791 post-embryonic development
GO:0016055 Wnt signaling pathway
GO:0031017 exocrine pancreas development
GO:0035264 multicellular organism growth
GO:0042127 regulation of cell proliferation
GO:0045595 regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055123 digestive system development
GO:0061113 pancreas morphogenesis
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28153
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281139
UniGene Bt.4522
RefSeq NP_776473
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149525 M80838
GenPept AAA98525 AAI49526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca