Version 5.4
Bos taurus Protein: ATG3
Summary
InnateDB Protein IDBP-683903.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG3
Protein Name Ubiquitin-like-conjugating enzyme ATG3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011976
InnateDB Gene IDBG-632300 (ATG3)
Protein Structure
UniProt Annotation
Function E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0019776 Atg8 ligase activity
GO:0019777 Atg12 ligase activity
GO:0019787 small conjugating protein ligase activity
GO:0019899 enzyme binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000422 mitochondrion degradation
GO:0006464 cellular protein modification process
GO:0006810 transport
GO:0006914 autophagy
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0044804 nucleophagy
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0000153 cytoplasmic ubiquitin ligase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007134 Autophagy-related protein 3, N-terminal
IPR007135 Autophagy-related protein 3
IPR019461 Autophagy-related protein 3, C-terminal
PFAM PF03986
PF03987
PF10381
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VCL3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508571
UniGene Bt.42695
RefSeq NP_001068832
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120110
GenPept AAI20111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca