InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CD200R1

Summary

InnateDB Protein

IDBP-683931.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD200R1

Protein Name

Cell surface glycoprotein CD200 receptor 1

Synonyms

CD200R1; CD200R2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001635

InnateDB Gene

IDBG-632323 (CD200R1)

Protein Structure

UniProt Annotation

Function

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5D7V5