InnateDB Protein
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IDBP-684023.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPTSSA
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Protein Name
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Small subunit of serine palmitoyltransferase A
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Synonyms
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C14orf147; C21H14orf147; ssSPTa;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000018578
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InnateDB Gene
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IDBG-632417 (SPTSSA)
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Protein Structure
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Function |
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR024512
Small subunit of serine palmitoyltransferase-like
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PFAM |
PF11779
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5E978
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
615641
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UniGene |
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RefSeq |
NP_001181971
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC134492
BT021042
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GenPept |
AAI34493
AAX09059
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