InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SLC6A4

Summary

InnateDB Protein

IDBP-684061.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A4

Protein Name

sodium-dependent serotonin transporter

Synonyms

SERT;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025774

InnateDB Gene

IDBG-632442 (SLC6A4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005335	serotonin:sodium symporter activity
GO:0005515	protein binding
GO:0008504	monoamine transmembrane transporter activity
GO:0015222	serotonin transmembrane transporter activity
GO:0015293	symporter activity
GO:0017137	Rab GTPase binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0006837	serotonin transport
GO:0009636	response to toxic substance
GO:0010628	positive regulation of gene expression
GO:0015844	monoamine transport
GO:0021794	thalamus development
GO:0035176	social behavior
GO:0045787	positive regulation of cell cycle
GO:0046621	negative regulation of organ growth
GO:0048854	brain morphogenesis
GO:0051610	serotonin uptake
GO:0055085	transmembrane transport
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000175 Sodium:neurotransmitter symporter
IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminal

PFAM

PF00209
PF03491

PRINTS

PR00176
PR01203

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MLI6

UniProt Splice Variant

Entrez Gene

282365

UniGene

Bt.4795

RefSeq

NP_777034

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02048626

GenPept