InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RACGAP1

Summary

InnateDB Protein

IDBP-684062.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RACGAP1

Protein Name

Rac GTPase activating protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016988

InnateDB Gene

IDBG-632426 (RACGAP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0043014	alpha-tubulin binding
GO:0043015	gamma-tubulin binding
GO:0046872	metal ion binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0000915	cytokinesis, actomyosin contractile ring assembly
GO:0007108	cytokinesis, initiation of separation
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007405	neuroblast proliferation
GO:0008272	sulfate transport
GO:0009790	embryo development
GO:0032467	positive regulation of cytokinesis
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0051256	spindle midzone assembly involved in mitosis
GO:0051988	regulation of attachment of spindle microtubules to kinetochore

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032154	cleavage furrow
GO:0051233	spindle midzone
GO:0070062	extracellular vesicular exosome
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008936 Rho GTPase activation protein
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00620
PF00130

PRINTS

PIRSF

SMART

SM00324
SM00109
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite