InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EIF2AK2

Summary

InnateDB Protein

IDBP-684095.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2AK2

Protein Name

interferon-induced, double-stranded RNA-activated protein kinase

Synonyms

PKR; PRKR;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011469

InnateDB Gene

IDBG-632472 (EIF2AK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003725	double-stranded RNA binding
GO:0003743	translation initiation factor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001819	positive regulation of cytokine production
GO:0006412	translation
GO:0006413	translational initiation
GO:0006468	protein phosphorylation
GO:0009615	response to virus
GO:0016310	phosphorylation
GO:0017148	negative regulation of translation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032722	positive regulation of chemokine production
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0033689	negative regulation of osteoblast proliferation
GO:0035455	response to interferon-alpha
GO:0043066	negative regulation of apoptotic process
GO:0045071	negative regulation of viral genome replication
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1900225	regulation of NLRP3 inflammasome complex assembly
GO:1901224	positive regulation of NIK/NF-kappaB signaling
GO:1901532	regulation of hematopoietic progenitor cell differentiation
GO:1902033	regulation of hematopoietic stem cell proliferation
GO:1902036	regulation of hematopoietic stem cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014720 Double-stranded RNA-binding domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00035

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00358
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A0JNE6

UniProt Splice Variant

Entrez Gene

347700

UniGene

Bt.20923

RefSeq

NP_835210

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126646 DAAA02030562 DAAA02030563 DAAA02030564

GenPept

AAI26647