Version 5.4
Bos taurus Protein: TMBIM6
Summary
InnateDB Protein IDBP-684109.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMBIM6
Protein Name Bax inhibitor 1
Synonyms TEGT;
Species Bos taurus
Ensembl Protein ENSBTAP00000043666
InnateDB Gene IDBG-632492 (TMBIM6)
Protein Structure
UniProt Annotation
Function Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0006986 response to unfolded protein
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006214 Bax inhibitor 1-related
PFAM PF01027
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0V882
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 616210
UniGene Bt.53719
RefSeq NP_001069882
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149995 BT026337
GenPept AAI49996 ABG81493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca