Version 5.4
Bos taurus Protein: TPPP
Summary
InnateDB Protein IDBP-684116.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPPP
Protein Name Tubulin polymerization-promoting protein
Synonyms p25;
Species Bos taurus
Ensembl Protein ENSBTAP00000054983
InnateDB Gene IDBG-632500 (TPPP)
Protein Structure
UniProt Annotation
Function May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. {ECO:0000269PubMed:14623963}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Brain-specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0031334 positive regulation of protein complex assembly
GO:0032273 positive regulation of protein polymerization
GO:0046785 microtubule polymerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008907 P25-alpha
PFAM PF05517
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q27957
PhosphoSite PhosphoSite-Q27957
TrEMBL
UniProt Splice Variant
Entrez Gene 280968
UniGene Bt.42
RefSeq NP_776401
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133343 X85738
GenPept AAI33344 CAA59741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca