InnateDB Protein
|
IDBP-684220.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TIMM22
|
Protein Name
|
Mitochondrial import inner membrane translocase subunit Tim22
|
Synonyms
|
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000011080
|
InnateDB Gene
|
IDBG-632594 (TIMM22)
|
Protein Structure
|
|
Function |
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003397
Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24
|
PFAM |
PF02466
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5BIN4
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
515555
|
UniGene |
Bt.8735
|
RefSeq |
NP_001029670
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC148116
BT021190
|
GenPept |
AAI48117
AAX31372
|
|
|