Version 5.4
Homo sapiens Protein: TFCP2L1
Summary
InnateDB Protein IDBP-68437.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFCP2L1
Protein Name transcription factor CP2-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263707
InnateDB Gene IDBG-68435 (TFCP2L1)
Protein Structure
UniProt Annotation
Function Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1. {ECO:0000250, ECO:0000269PubMed:10644752}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10644752}.
Disease Associations
Tissue Specificity Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue. {ECO:0000269PubMed:10644752}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 96 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0002070 epithelial cell maturation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006694 steroid biosynthetic process
GO:0007028 cytoplasm organization
GO:0007431 salivary gland development
GO:0007565 female pregnancy
GO:0008340 determination of adult lifespan
GO:0045927 positive regulation of growth
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR007604 CP2 transcription factor
IPR013761 Sterile alpha motif/pointed domain
PFAM PF04516
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZI6
PhosphoSite PhosphoSite-Q9NZI6
TrEMBL Q5JV87
UniProt Splice Variant
Entrez Gene 29842
UniGene Hs.743125
RefSeq NP_055368
HUGO HGNC:17925
OMIM 609785
CCDS CCDS2134
HPRD 18175
IMGT
EMBL AC013399 AC079988 AF198488 AL137740 BC064698
GenPept AAF32275 AAH64698 AAX88871 AAY24072 CAI46212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca