InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: INPP5K

Summary

InnateDB Protein

IDBP-684401.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP5K

Protein Name

inositol polyphosphate 5-phosphatase K

Synonyms

SKIP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015257

InnateDB Gene

IDBG-632749 (INPP5K)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding
GO:0016312	inositol bisphosphate phosphatase activity
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
GO:0046030	inositol trisphosphate phosphatase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001933	negative regulation of protein phosphorylation
GO:0005979	regulation of glycogen biosynthetic process
GO:0006469	negative regulation of protein kinase activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010829	negative regulation of glucose transport
GO:0016311	dephosphorylation
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035305	negative regulation of dephosphorylation
GO:0035810	positive regulation of urine volume
GO:0042593	glucose homeostasis
GO:0043407	negative regulation of MAP kinase activity
GO:0043922	negative regulation by host of viral transcription
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0051497	negative regulation of stress fiber assembly
GO:0051898	negative regulation of protein kinase B signaling
GO:0051926	negative regulation of calcium ion transport
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072661	protein targeting to plasma membrane
GO:0090315	negative regulation of protein targeting to membrane
GO:0097178	ruffle assembly
GO:2000466	negative regulation of glycogen (starch) synthase activity
GO:2001153	positive regulation of renal water transport

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase
IPR012852 Coiled-coil transcriptional coactivator-like

PFAM

PF03372
PF14529
PF07888

PRINTS

PIRSF

SMART

SM00128

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite