Version 5.4
Bos taurus Protein: WNT2
Summary
InnateDB Protein IDBP-684432.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT2
Protein Name Protein Wnt-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010650
InnateDB Gene IDBG-632785 (WNT2)
Protein Structure
UniProt Annotation
Function Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060492 lung induction
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060716 labyrinthine layer blood vessel development
GO:0061180 mammary gland epithelium development
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR005817 Wnt
IPR009140 Wnt-2 protein
PFAM PF00110
PRINTS PR01349
PR01842
PIRSF
SMART SM00097
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4D7S0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 493729
UniGene Bt.37360
RefSeq NP_001013019
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DP000008
GenPept AAR16261

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca