InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SETD6

Summary

InnateDB Protein

IDBP-684469.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETD6

Protein Name

N-lysine methyltransferase SETD6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027690

InnateDB Gene

IDBG-632801 (SETD6)

Protein Structure

UniProt Annotation

Function

Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0016279	protein-lysine N-methyltransferase activity
GO:0016740	transferase activity
GO:0051059	NF-kappaB binding

Biological Process

GO:0018026	peptidyl-lysine monomethylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032259	methylation
GO:0050727	regulation of inflammatory response

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR011383 RuBisCO-cytochrome methylase, RMS1
IPR015353 Rubisco LSMT, substrate-binding domain

PFAM

PF00856
PF09273

PRINTS

PIRSF

PIRSF011771

SMART

SM00317

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

E1BI64

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539651

UniGene

RefSeq

XP_005218752

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AAFC03050240 BC140545

GenPept

AAI40546