Version 5.4
Bos taurus Protein: S100A13
Summary
InnateDB Protein IDBP-684480.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A13
Protein Name Protein S100-A13
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028499
InnateDB Gene IDBG-632825 (S100A13)
Protein Structure
UniProt Annotation
Function Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Secretion is mediated by exposure to stress and requires copper ions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0017134 fibroblast growth factor binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0006810 transport
GO:0015031 protein transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043303 mast cell degranulation
GO:0050663 cytokine secretion
GO:0050703 interleukin-1 alpha secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042629 mast cell granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
PFAM PF01023
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P79342
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 404146
UniGene Bt.36848
RefSeq NP_991369
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB001567 BC103266
GenPept AAI03267 BAA19411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca