Version 5.4
| Bos taurus Protein: CLDN10 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-684494.2 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | CLDN10 | ||||||||||||
| Protein Name | Claudin-10 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Protein | ENSBTAP00000004641 | ||||||||||||
| InnateDB Gene | IDBG-632832 (CLDN10) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney (By similarity). {ECO:0000250}. | ||||||||||||
| Subcellular Localization | Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | |||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | |||||||||||||
| InterPro |
IPR003554
Claudin-10 IPR004031 PMP-22/EMP/MP20/Claudin superfamily IPR006187 Claudin |
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| PFAM |
PF00822
PF13903 |
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| PRINTS |
PR01383
PR01077 |
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| PIRSF | |||||||||||||
| SMART | |||||||||||||
| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q5E9L0 | ||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 506545 | ||||||||||||
| UniGene | Bt.16487 | ||||||||||||
| RefSeq | NP_001014857 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC153270 BT020910 DAAA02034568 DAAA02034569 DAAA02034570 DAAA02034571 DAAA02034572 | ||||||||||||
| GenPept | AAI53271 AAX08927 | ||||||||||||