Version 5.4
Bos taurus Protein: LALBA
Summary
InnateDB Protein IDBP-684514.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LALBA
Protein Name Alpha-lactalbumin
Synonyms a-LACTA; alfaLA;
Species Bos taurus
Ensembl Protein ENSBTAP00000007701
InnateDB Gene IDBG-632851 (LALBA)
Protein Structure
UniProt Annotation
Function Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Mammary gland specific. Secreted in milk.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004461 lactose synthase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0005989 lactose biosynthetic process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000545 Lactalbumin
IPR000974 Glycoside hydrolase, family 22, lysozyme
IPR001916 Glycoside hydrolase, family 22
IPR023346 Lysozyme-like domain
PFAM PF00062
PF13406
PRINTS PR00136
PR00137
PR00135
PIRSF
SMART SM00263
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00711
PhosphoSite PhosphoSite-
TrEMBL B6V3I5
UniProt Splice Variant
Entrez Gene 281894
UniGene Bt.87412
RefSeq NP_776803
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB052163 AB052164 AB052165 AB052166 AB052167 AF249896 BC102173 BT025469 FJ232912 J05147 M18780 M90645 X06366
GenPept AAA30367 AAA30614 AAA30615 AAF63624 AAI02174 ABF57425 ACI62509 BAB18921 BAB18922 BAB18923 BAB18924 BAB18925 CAA29664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca