InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE3B

Summary

InnateDB Protein

IDBP-684550.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE3B

Protein Name

phosphodiesterase 3B, cGMP-inhibited

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006874

InnateDB Gene

IDBG-632846 (PDE3B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0016525	negative regulation of angiogenesis
GO:0031018	endocrine pancreas development
GO:0042593	glucose homeostasis
GO:0050796	regulation of insulin secretion
GO:0050995	negative regulation of lipid catabolic process

Cellular Component

GO:0016020	membrane
GO:0032045	guanyl-nucleotide exchange factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain

PFAM

PF00233

PRINTS

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BN64

UniProt Splice Variant

Entrez Gene

533323

UniGene

RefSeq

XP_002693091

HUGO

HGNC:8779

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02040625 DAAA02040626 DAAA02040627

GenPept