Version 5.4
Bos taurus Protein: SERPINF1
Summary
InnateDB Protein IDBP-684561.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINF1
Protein Name Pigment epithelium-derived factor
Synonyms PEDF;
Species Bos taurus
Ensembl Protein ENSBTAP00000012804
InnateDB Gene IDBG-632896 (SERPINF1)
Protein Structure
UniProt Annotation
Function Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Subcellular Localization Secreted. Melanosome {ECO:0000250}.
Disease Associations
Tissue Specificity Retinal pigment epithelial cells. Located in the interphotoreceptor matrix (IPM) which is between the retinal pigment epithelium and the neural retina.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0016525 negative regulation of angiogenesis
GO:0030162 regulation of proteolysis
GO:0050769 positive regulation of neurogenesis
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95121
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281386
UniGene Bt.2638
RefSeq NP_776565
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF017058 BC112656 U48229
GenPept AAC05732 AAC48856 AAI12657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca