Version 5.4
Bos taurus Protein: GDI1
Summary
InnateDB Protein IDBP-684646.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDI1
Protein Name Rab GDP dissociation inhibitor alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016093
InnateDB Gene IDBG-632982 (GDI1)
Protein Structure
UniProt Annotation
Function Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269PubMed:11208110, ECO:0000269PubMed:12623022}.
Subcellular Localization Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005093 Rab GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0032482 Rab protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0050771 negative regulation of axonogenesis
GO:0050790 regulation of catalytic activity
GO:0090315 negative regulation of protein targeting to membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro IPR000806 Rab GDI protein
IPR018203 GDP dissociation inhibitor
PFAM PF00996
PRINTS PR00892
PR00891
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21856
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281188
UniGene Bt.2235
RefSeq NP_776489
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123440 D90103
GenPept AAI23441 BAA14134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca