Version 5.4
Bos taurus Protein: GOT2
Summary
InnateDB Protein IDBP-684661.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GOT2
Protein Name Aspartate aminotransferase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009440
InnateDB Gene IDBG-632996 (GOT2)
Protein Structure
UniProt Annotation
Function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix. Cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0044822 poly(A) RNA binding
GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006520 cellular amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006533 aspartate catabolic process
GO:0006536 glutamate metabolic process
GO:0006810 transport
GO:0006869 lipid transport
GO:0009058 biosynthetic process
GO:0015908 fatty acid transport
GO:0019550 glutamate catabolic process to aspartate
GO:0019551 glutamate catabolic process to 2-oxoglutarate
GO:0045471 response to ethanol
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000796 Aspartate/other aminotransferase
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00155
PRINTS PR00799
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12344
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 286886
UniGene Bt.1316
RefSeq NP_777231
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102303 BT030486 Z25466
GenPept AAI02304 ABQ12926 CAA80960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca