Version 5.4
Homo sapiens Protein: DYNLRB1
Summary
InnateDB Protein IDBP-68468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYNLRB1
Protein Name dynein, light chain, roadblock-type 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349679
InnateDB Gene IDBG-68466 (DYNLRB1)
Protein Structure
UniProt Annotation
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients. {ECO:0000269PubMed:11750132}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006810 transport
GO:0007018 microtubule-based movement
GO:0007632 visual behavior
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR004942 Dynein light chain-related
IPR016561 Dynein light chain, roadblock-type
PFAM PF03259
PRINTS
PIRSF PIRSF009998
SMART SM00960
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP97
PhosphoSite PhosphoSite-Q9NP97
TrEMBL
UniProt Splice Variant
Entrez Gene 83658
UniGene
RefSeq NP_808852
HUGO HGNC:15468
OMIM 607167
CCDS CCDS13235
HPRD 06203
IMGT
EMBL AF132750 AF161511 AF165516 AF178431 AL109923 AL136173 AY026513 BC002481 BC007223
GenPept AAF29126 AAF86646 AAH02481 AAK18712 AAK95342 AAL75951 CAI21456 CAI23308 CAM28250 CAM28343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca