InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ENDOU

Summary

InnateDB Protein

IDBP-684702.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENDOU

Protein Name

Poly(U)-specific endoribonuclease

Synonyms

P11;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043168

InnateDB Gene

IDBG-633034 (ENDOU)

Protein Structure

UniProt Annotation

Function

Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004521	endoribonuclease activity
GO:0005044	scavenger receptor activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0007565	female pregnancy
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001212 Somatomedin B domain
IPR018998 Endoribonuclease XendoU
IPR020436 Somatomedin B, chordata

PFAM

PF01033
PF09412

PRINTS

PR00022

PIRSF

SMART

SM00201

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QLQ8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

525399

UniGene

Bt.61409

RefSeq

NP_001095560

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC148052

GenPept

AAI48053