InnateDB Protein
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IDBP-68472.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DYNLRB1
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Protein Name
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dynein, light chain, roadblock-type 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000300469
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InnateDB Gene
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IDBG-68466 (DYNLRB1)
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Protein Structure
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Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
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Subcellular Localization |
Cytoplasm, cytoskeleton.
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Disease Associations |
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Tissue Specificity |
High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients. {ECO:0000269PubMed:11750132}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003777
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microtubule motor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NP97
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PhosphoSite |
PhosphoSite-Q9NP97
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83658
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UniGene |
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RefSeq |
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HUGO |
HGNC:15468
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OMIM |
607167
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CCDS |
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HPRD |
06203
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IMGT |
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EMBL |
AF132750
AF161511
AF165516
AF178431
AL109923
AL136173
AY026513
BC002481
BC007223
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GenPept |
AAF29126
AAF86646
AAH02481
AAK18712
AAK95342
AAL75951
CAI21456
CAI23308
CAM28250
CAM28343
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