Bos taurus Protein: PPP1CC
Summary
InnateDB Protein IDBP-684858.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1CC
Protein Name Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000048567
InnateDB Gene IDBG-633173 (PPP1CC)
Protein Structure
UniProt Annotation
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cleavage furrow {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus speckle {ECO:0000250}. Midbody {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. Colocalizes with SPZ1 in the nucleus. Colocalizes with URI1 at mitochondrion (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 186 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 186 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0048511 rhythmic process
GO:0051301 cell division
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016607 nuclear speck
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0043234 protein complex
GO:0070688 MLL5-L complex
GO:0072357 PTW/PP1 phosphatase complex
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS PR00114
PIRSF
SMART SM00156
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61287
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282318
UniGene Bt.9578
RefSeq NP_777006
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ429235 BC123502
GenPept AAI23503 CAD22157