InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PPIP5K1

Summary

InnateDB Protein

IDBP-684895.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIP5K1

Protein Name

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Synonyms

HISPPD2A;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018635

InnateDB Gene

IDBG-633199 (PPIP5K1)

Protein Structure

UniProt Annotation

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0003993	acid phosphatase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0033857	diphosphoinositol-pentakisphosphate kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0006020	inositol metabolic process
GO:0016310	phosphorylation
GO:0016311	dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000560 Histidine phosphatase superfamily, clade-2
IPR029033 Histidine phosphatase superfamily

PFAM

PF00328

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7Z050

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

510684

UniGene

Bt.27184

RefSeq

NP_001098824

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC153248

GenPept

AAI53249