Version 5.4
Bos taurus Protein: PRUNE
Summary
InnateDB Protein IDBP-684959.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRUNE
Protein Name Protein prune homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020388
InnateDB Gene IDBG-633263 (PRUNE)
Protein Structure
UniProt Annotation
Function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004427 inorganic diphosphatase activity
GO:0005515 protein binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR001667 DDH domain
IPR004097 DHHA2 domain
PFAM PF01368
PF02833
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9Y6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 524973
UniGene Bt.4857
RefSeq NP_001030429
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142289 BT020783
GenPept AAI42290 AAX08800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca