InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CTNS

Summary

InnateDB Protein

IDBP-684961.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNS

Protein Name

Cystinosin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000049590

InnateDB Gene

IDBG-633262 (CTNS)

Protein Structure

UniProt Annotation

Function

Thought to transport cystine out of lysosomes.

Subcellular Localization

Lysosome membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015184	L-cystine transmembrane transporter activity

Biological Process

GO:0002088	lens development in camera-type eye
GO:0006749	glutathione metabolic process
GO:0006810	transport
GO:0007420	brain development
GO:0007616	long-term memory
GO:0007625	grooming behavior
GO:0007628	adult walking behavior
GO:0008542	visual learning
GO:0015811	L-cystine transport
GO:0046034	ATP metabolic process
GO:0050890	cognition

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR005282 Lysosomal cystine transporter
IPR006603 PQ-loop repeat

PFAM

PF04193

PRINTS

PIRSF

SMART

SM00679

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7MB63

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613527

UniGene

Bt.13509

RefSeq

NP_001095734

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151357

GenPept

AAI51358