InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLL4

Summary

InnateDB Protein

IDBP-6850.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLL4

Protein Name

delta-like 4 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000249749

InnateDB Gene

IDBG-6848 (DLL4)

Protein Structure

UniProt Annotation

Function

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. {ECO:0000269PubMed:17728344, ECO:0000269PubMed:20616313}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in vascular endothelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001974	blood vessel remodeling
GO:0003208	cardiac ventricle morphogenesis
GO:0003209	cardiac atrium morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003344	pericardium morphogenesis
GO:0007154	cell communication
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007275	multicellular organismal development
GO:0007601	visual perception
GO:0008015	blood circulation
GO:0008285	negative regulation of cell proliferation
GO:0010596	negative regulation of endothelial cell migration
GO:0035912	dorsal aorta morphogenesis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0050767	regulation of neurogenesis
GO:0060579	ventral spinal cord interneuron fate commitment
GO:0061074	regulation of neural retina development
GO:0061314	Notch signaling involved in heart development
GO:0072554	blood vessel lumenization
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00051
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NR61